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LXE408 shows no inhibition of the hERG channel (IC50>30 μM) in a manual patch clamp assay
Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth
CAS Number: 78957-85-4
and Huh7 cells proliferation with IC50s of 5
G140 atrole LXE408 shows no inhibition ofG140 is a potent and selective inhibitor of cyclic GMP AMP synthase (cGAS), with IC50s of 14. 0 nM and 442 nM for h cGAS and m cGAS, respectively. G140 has anti inflammatory activity. Product information CAS Number: 2369751 07 3 Molecular Weight: 379. 24 Formula: C17H16Cl2N4O2 Chemical Name: 1 [6,7 dichloro 9 (1 methyl 1H pyrazol 3 yl) 1H,2H,3H,4H,5H pyrido[4,3 b]indol 2 yl] 2 hydroxyethan 1 one Smiles:
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