GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 Treatment of primary inv(16) AML

Treatment of primary inv(16) AML patient blasts with AI-10-49 triggers selective cell death

Storage Condition: Powder: 4oC for 1 year

is a novel potent and selective SETD7 histone lysine methyltransferase inhibitor with IC50 ~2 nM

and DY131 delays progression from prophase to anaphase

GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 Treatment of primary inv(16) AMLGNF 7, CAS No. 839706 07 9, is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF 7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. Product information CAS Number: 839706 07 9 Molecular Weight: 547. 53