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They work against mill in a similar fashion: Shuffling your library back into your deck against a mill deck is equivalent to resetting your life total to 20, 40, or whatever against a more standard Magic deck attacking your life total

Here is Exhibit A, I could find an Exhibit B if you needed it, but I kind of feel like anyone who needed that would have acquitted OJ

Other commanders you could choose are Sivriss, Nightmare Speaker who can mill up to three cards by sacrificing a creature or Erinis, Gloom Stalker

As a side note, the fact that your opponent will have to spend mana on a combat trick instead of anything else (like casting another creature) should make you more inclined to block