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Smiles: COC1=CC=CC(OCCCN)=C1C1=CC(NC2=CN=C(C=N2)C#N)=NN1
Epothilone B competes with Taxol in binding to microtubules
It retains the activity of later-generation cephalosporins having broad-spectrum activity against Gram-negative bacteria
23(3):427-40
Ro 48-8071 viol Smiles: COC1=CC=CC(OCCCN)=C1C1=CC(NC2=CN=C(C=N2)C#N)=NN1Ro 48 8071 is an orally active cholesterol synthesis inhibitor or a 2,3 oxidosqualene: lanosterol cyclase (OSC) inhibitor. OSC (EC 5. 4. 99. 7) represents a unique target for a cholesterol lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG CoA reductase expression, generating a synergistic, self limited negative regulatory loop.