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Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms
Formula: C16H15BrN2O5S
2020 Apr 15
and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2
Vadimezan (DMXAA) Size:2mg solid Hedgehog signaling antagonist GDC-0449 (Vismodegib)Vadimezan, also known as DMXAA and ASA404, is a fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti tumor activity of tumor associated macrophages. Product information CAS Number: 117570 53 3 Molecular Weight: 282. 29
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