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biochemically
Phase I study of TAS-102 and irinotecan combination therapy in Japanese patients with advanced colorectal cancer
1 mg/kg (p
Ribeiro JR
Spautin-1 - Autophagy Inhibitor. CAS# 1262888-28-7 Catalog No.:M60003-10S biochemicallySpautin 1, CAS No. 1262888 28 7, is a potent autophagy inhibitor with an IC50 ~0. 74 M, and was discovered by an imaging based screen. It can selectively promote the degradation of Vps34 complexes. Mechanistic studies showed that Spautin 1 inhibited two ubiquitin specific peptidases, USP10 and USP13, which target the Beclin1 subunit of Vps34 complexes. Since USP10 mediates the deubiquitination of p53, regulating deubiquitination activity of USP10 and
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