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without body weight loss and blood cell count decrease
CAS Number: 1227158-85-1
Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39
1996 Jan 5
GSK-2606414 - CAS# 1337531-36-8 0435 without body weight loss andGSK 2606414, CAS No. 1337531 36 8, is an orally available, potent, and selective PERK inhibitor. GSK 2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR) like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival
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