Glipizide-d11 14451 with an EC50 and IC50

with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays

Treatment of autologous CLL-T cell co-cultures with Lenalidomide reverses impaired CD8+ T cell lytic synapse formation and granzyme B trafficking

Mice treated with 100 mg/kg have a mean weight loss of >20% with no return to their baseline starting weight

Chemical Name: 2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]-N-methylbenzamide

Glipizide-d11 14451 with an EC50 and IC50Product information CAS Number: 1189426 07 0 Molecular Weight: 456. 60 Formula: C21H27N5O4S Chemical Name: N (2 {4 [({[(1,2,2,3,3,4,4,5,5,6,6 H)cyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl) 5 methylpyrazine 2 carboxamide Smiles: [2H]C1(NC(=O)NS(=O)(=O)C2=CC=C(CCNC(=O)C3=CN=C(C)C=N3)C=C2)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H] InChiKey: ZJJXGWJIGJFDTL KVEFGMAKSA N InChi: InChI=1S C21H27N5O4S c1 15 13 24 19(14 23 15)20(27)22