AKT-IN-5 ercetin 3-O-(6''-galloyl)-β-D-galactopyranoside Dimerizer drug AP1903 homodimerizes an

Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity

CC1=C[C@H](C)[C@@H](O)[C@H](C[C@H](C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(C)=CC=C[C@H](OC)[C@H]1OC(N)=O)C2=O)OC |c:1

6-Chloro-1-tetralone is an important intermediate for the synthesis of pharmaceutical compounds

InChi: InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7

AKT-IN-5 ercetin 3-O-(6''-galloyl)-β-D-galactopyranoside Dimerizer drug AP1903 homodimerizes anAKT IN 5 (Example 8) is a Akt inhibitor with IC50 values of 450 nM and 400 nM for Akt1 and Akt2, respectively. Product information CAS Number: 1402608 05 2 Molecular Weight: 384. 43 Formula: C23H20N4O2 Chemical Name: 2 [4 (1 aminocyclobutyl)phenyl] 3 phenylimidazo[1, 2 b]pyridazine 6 carboxylic acid Smiles: NC1(CCC1)C1C=CC(=CC=1)C1N=C2C=CC(=NN2C=1C1C=CC=CC=1)C(O)=O InChiKey: OWPDGTJNKVXYND UHFFFAOYSA N InChi: InChI=1S C23H20N4O2 c24 23(13 4 14 23)17 9