CAL-130 Hydrochloride - CAS# 1431697-78-7 60153 In a recent study of

In a recent study of pancreatic explants

InChi: InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6

full IC50 determinations is performed for VU0364770 at the MAO-A and MAO-B isoforms

Kadoshima T

CAL-130 Hydrochloride - CAS# 1431697-78-7 60153 In a recent study ofCAL 130 is a potent and selective PI3K gamma and delta inhibitor with potential anticancer activity. Constitutive phosphoinositide 3 kinase (PI3K) Akt activation is common in T cell acute lymphoblastic leukemia (T ALL). Although four distinct class I PI3K isoforms (, , , ) could participate in T ALL pathogenesis, none has been implicated in this process. In the absence of PTEN phosphatase tumor suppressor function, PI3K or PI3K alone can support