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CGK733 (10 μM) causes the loss of cyclin D1 through the ubiquitin-dependent proteasomal degradation pathway in MCF-7 and T47D breast cancer cell lines
H-1152 2HCl
CAS Number: 1314890-29-3
Lajczak NK
Eg5 Inhibitor III - CAS# 863774-58-7 Catalog No.:M6537-2 CGK733 (10 μM) causes theEg5 Inhibitor III, CAS No. 863774 58 7, is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Eg5 Inhibitor III suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. Product
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