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Vuylsteke P
Fedratinib
GSK0660 (1 μM) markedly blocks GW501516-mediated attenuation of glutamate release
8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental pollutant with many toxic effects
WDR5-C47 - WDR5-MLL (SET1) Antagonist. CAS# 1422389-91-0 0020 Vuylsteke PWDR5 C47, CAS No. 1422389 91 0, is a highly potent and selective antagonist of WDR5 MLL interaction with an IC50 ~0. 3 M. WDR5 C47 was designed based on the structure of the WDR5 MLL complex. The WD40 repeat protein WDR5 plays a critical role in maintaining the integrity of the MLL complex and fully activating its methyltransferase function. The MLL complex, the trithorax like family of SET1 methyltransferase, catalyzes trimethylation of lysine 4 on
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