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37 and 97% TGI
54 mg/kg (pAKTS473)
170:226-33
Nutlin-3 can block the MDMX–p53 interaction and induce the p53 pathway in retinoblastoma cells (Weri1) with IC50 of 0
CHIR-124 Size:10mg solid 37 and 97% TGICHIR 124 is a quinolone based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0. 0003 micromol L). CHIR 124 interacts synergistically with topoisomerase poisons (e. g., camptothecin or SN 38) in causing growth inhibition in several p53 mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR 124 is a novel
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