GS-444217 LSB 27(12):2992-3000

27(12):2992-3000

Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment

Behav Pharmacol

Reduced VEGF production

GS-444217 LSB 27(12):2992-3000GS 444217 (ASK1 IN 1) is a potent, selective, orally available and ATP competitive inhibitor of ASK1 (apoptosis signal regulating kinase 1) with IC50 of 2. 87 nM. Product information CAS Number: 1262041 49 5 Molecular Weight: 411. 46 Formula: C23H21N7O Synonym: ASK1 IN 1 Chemical Name: 4 (4 Cyclopropyl 1H imidazol 1 yl) N (3 (4 cyclopropyl 4H 1,2,4 triazol 3 yl)phenyl)picolinamide Smiles: O=C(NC1=CC(=CC=C1)C1=NN=CN1C1CC1)C1=CC(=CC=N1)N1C=C(N=C1)C1CC1