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11(2):164-71
Hoflack JC
8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1
PMID: 30826187
IPA-3 Size:2mg solid 11(2):164-71IPA 3 is a potent and selective PAK1 inhibitor. IPA 3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF B activation. IPA 3 treatment significantly inhibited the growth of HCC cells. The mechanisms through which IPA 3 treatment suppresses HCC cell growth are enhancement of apoptosis and blockage of activation of NF B. IPA 3 not only inhibits the HCC cell growth, but also suppresses the metastatic potential of HCC cells. Nude mouse
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