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Doripenem is the most active carbapenem (MIC90
2013 Nov 21
Althouth displaying little antiproliferative activity on cell growth of HUVECs alone
1999398A3P
TAK-733 0162 Doripenem is the most activeTAK 733 is an orally bioavailable small molecule inhibitor of MEK1 and MEK2 (MEK1 2) with potential antineoplastic activity. MEK inhibitor TAK 733 selectively binds to and inhibits the activity of MEK1 2, preventing the activation of MEK1 2 dependent effector proteins and transcription factors, which may result in the inhibition of growth factor mediated cell signaling and tumor cell proliferation. MEK1 2 (MAP2K1 K2) are dual specificity threonine
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